Norway researchers probe cancer treatment-malaria medicine connection / News / The Foreigner

The Foreigner Norway researchers probe cancer treatment-malaria medicine connection. Scientists glean valuable information on how cancer develops, according to Norwegian research into the disease conducted in fruit flies. The cancer cells in the insects were shown to engulf heathy cells to use as nourishment. A chemical message from the cancer cell will trick nearby cells into consuming themselves – known as autophagy. Autophagy, from the Greek words “auto” and “phagy”, meaning “self” and “eating”, respectively, deals with destruction of cells in the body.

medicine, cancer, chemotherapy, radiotherapy, research, treatment, malaria, paywall



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Norway researchers probe cancer treatment-malaria medicine connection

Published on Monday, 16th January, 2017 at 13:05 under the news category, by Sarah Bostock.

Scientists glean valuable information on how cancer develops, according to Norwegian research into the disease conducted in fruit flies.



The cancer cells in the insects were shown to engulf heathy cells to use as nourishment. A chemical message from the cancer cell will trick nearby cells into consuming themselves – known as autophagy.

Autophagy, from the Greek words “auto” and “phagy”, meaning “self” and “eating”, respectively, deals with destruction of cells in the body.

It is a normal self-degradative physiological process important for balancing sources of energy at critical times in development, removing aggregated proteins.

Thought of as a being survival mechanism, and key to preventing diseases such as cancer, liver disease, and infections, it also kills the cells under certain conditions – a form of programmed cell death (PCD).

Norwegian scientists discovered that the cancer cells trick neighbouring cells into dying, giving the diseased ones the opportunity to grow.

PhD student Nadja Katheder at the Oslo University Hospital’s Radium Hospital explains, who conducted research in collaboration with Tor Erik Rusten, explains that they lined cancer in the tumour with amino acids and sugar from neighbouring cells.

“The question was whether it was relevant to the growth of the tumour. Blocking of autophagy in the neighbouring cells around has shown us how nutrition from neighbouring cells is essential for cancer development,” she told NRK.

The results from the research are supported by similar findings regarding human cells taken from patients with pancreatic cancer, in whom building blocks such as amino acids are transferred between healthy neighboring cells and ones infected with cancer.

Researchers are now aiming to use drugs such Choloroquine, a malaria medicine, to stop tumors from growing. Inhibiting this would be achieved by blocking cancer cells from obtaining nourishment from their surroundings.

“This, in conjunction with chemotherapy and radiotherapy, should be able to shrink a cancerous tumor.”

At the same time, stopping authophagy can lead to problems with the nervous system over time, including diseases such as Alzheimer’s and Parkinson’s.

“But this will not prevent making cancer treatment more effective for shorter periods,” Tor Erik Rusten also explained to the Norwegian broadcaster.

Researchers’ findings are published in research journal Nature.



Published on Monday, 16th January, 2017 at 13:05 under the news category, by Sarah Bostock.

This post has the following tags: medicine, cancer, chemotherapy, radiotherapy, research, treatment, malaria, paywall.





  
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